Discovery and development of natural heat shock protein 90 inhibitors in cancer treatment
Heat shock protein 90 (Hsp90) is a highly conserved molecular chaperone that plays a vital role in the signal transduction of cancers. Hsp90 inhibitors are able to inhibit Hsp90 or the complex of Hsp90 and co-chaperones resulting in the degradation of Hsp90-dependent client proteins through the ubiq...
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| Main Authors: | , , , , , , |
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| Format: | Book |
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Elsevier,
2012-06-01T00:00:00Z.
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| 001 | doaj_787060c1106a466b97f43352c8a7b03f | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Yong Li |e author |
| 700 | 1 | 0 | |a Dongmei Zhang |e author |
| 700 | 1 | 0 | |a Jun Xu |e author |
| 700 | 1 | 0 | |a Junmin Shi |e author |
| 700 | 1 | 0 | |a Lei Jiang |e author |
| 700 | 1 | 0 | |a Nan Yao |e author |
| 700 | 1 | 0 | |a Wencai Ye |e author |
| 245 | 0 | 0 | |a Discovery and development of natural heat shock protein 90 inhibitors in cancer treatment |
| 260 | |b Elsevier, |c 2012-06-01T00:00:00Z. | ||
| 500 | |a 2211-3835 | ||
| 500 | |a 2211-3843 | ||
| 500 | |a 10.1016/j.apsb.2012.03.009 | ||
| 520 | |a Heat shock protein 90 (Hsp90) is a highly conserved molecular chaperone that plays a vital role in the signal transduction of cancers. Hsp90 inhibitors are able to inhibit Hsp90 or the complex of Hsp90 and co-chaperones resulting in the degradation of Hsp90-dependent client proteins through the ubiquitination-proteasome pathway, thereby leading to the growth inhibition of tumor cells. This review will briefly discuss the molecular structure and biological function of Hsp90, and focus on a summary of recent progress in the development and testing of natural Hsp90 inhibitors and their different means by which they interact with Hsp90. | ||
| 546 | |a EN | ||
| 690 | |a Heat shock protein 90 (Hsp90) | ||
| 690 | |a Tumor | ||
| 690 | |a Hsp90 inhibitors | ||
| 690 | |a Geldanamycin | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Acta Pharmaceutica Sinica B, Vol 2, Iss 3, Pp 238-245 (2012) | |
| 787 | 0 | |n http://www.sciencedirect.com/science/article/pii/S2211383512000639 | |
| 787 | 0 | |n https://doaj.org/toc/2211-3835 | |
| 787 | 0 | |n https://doaj.org/toc/2211-3843 | |
| 856 | 4 | 1 | |u https://doaj.org/article/787060c1106a466b97f43352c8a7b03f |z Connect to this object online. |