State-of-the-art automated patch clamp devices: Heat activation, action potentials and high throughput in ion channel screening

• Main Authors: Sonja eStoelzle (Author), Alison eObergrussberger (Author), Andrea eBruggemann (Author), Claudia eHaarmann (Author), Michael eGeorge (Author), Ralf Franz Kettenhofen (Author), Niels eFertig (Author)
• Format: Book
• Published: Frontiers Media S.A., 2011-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Ion channels are essential in a wide range of cellular functions and their malfunction underlies many disease states making them important targets in drug discovery. Diverse automated patch clamp systems with high-throughput capabilities are available for drug screening, but there are limitations in...