Development and Validation of a Novel UHPLC-MS/MS Method for the Quantification of Plinabulin in Plasma and Its Application in a Pharmacokinetic Study with Leukopenic Rats

• Main Authors: Xiaochen Niu (Author), Dan Chen (Author), Wei He (Author), Yu Tang (Author), Jianchun Zhao (Author)
• 格式: 图书
• 出版: MDPI AG, 2023-08-01T00:00:00Z.
• 主题: article
• 在线阅读: Connect to this object online.

Plinabulin, a new antitumor drug developed from marine natural products that targets microtubules in cancer cells, is currently being tested in a phase III clinical study. Plinabulin has been clinically proven to be effective on leukopenia. However, to our knowledge, there are no reports investigati...