Targeted Immunotherapy with Rituximab Leads to a Transient Alteration of the IgG Autoantibody Profile in Pemphigus Vulgaris

• Main Authors: Ralf Müller (Author), Nicolas Hunzelmann (Author), Vera Baur (Author), Guido Siebenhaar (Author), Elke Wenzel (Author), Rüdiger Eming (Author), Andrea Niedermeier (Author), Philippe Musette (Author), Pascal Joly (Author), Michael Hertl (Author)
• Format: Book
• Published: Hindawi Limited, 2010-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In pemphigus vulgaris (PV), IgG autoantibodies against the ectodomain of desmoglein 3 (Dsg3) have been shown to be directly responsible for the loss of keratinocyteadhesion. The aim of the present study was to study the effect of the B cell depleting anti-CD20 monoclonal antibody, rituximab, on the...