Sphingosine 1-Phosphate Signaling as a Target in Hepatic Fibrosis Therapy

• Autori principali: Bárbara González-Fernández (Autore), Diana I. Sánchez (Autore), Javier González-Gallego (Autore), María J. Tuñón (Autore)
• Natura: Libro
• Pubblicazione: Frontiers Media S.A., 2017-08-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Liver fibrosis is an excess production of extracellular matrix proteins as a result of chronic liver disease which leads to cell death and organ dysfunction. The key cells involved in fibrogenesis are resident hepatic stellate cells (HSCs) which are termed myofibroblasts after activation, acquiring...