Changes in glucose-induced plasma active glucagon-like peptide-1 levels by co-administration of sodium-glucose cotransporter inhibitors with dipeptidyl peptidase-4 inhibitors in rodents

• Main Authors: Takahiro Oguma (Author), Chiaki Kuriyama (Author), Keiko Nakayama (Author), Yasuaki Matsushita (Author), Kumiko Hikida (Author), Minoru Tsuda-Tsukimoto (Author), Akira Saito (Author), Kenji Arakawa (Author), Kiichiro Ueta (Author), Masabumi Minami (Author), Masaharu Shiotani (Author)
• Format: Book
• Published: Elsevier, 2016-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We investigated whether structurally different sodium-glucose cotransporter (SGLT) 2 inhibitors, when co-administered with dipeptidyl peptidase-4 (DPP4) inhibitors, could enhance glucagon-like peptide-1 (GLP-1) secretion during oral glucose tolerance tests (OGTTs) in rodents. Three different SGLT in...