Unlocking the therapeutic potential of P2X7 receptor: a comprehensive review of its role in neurodegenerative disorders

• Main Authors: Xiaoming Liu (Author), Yiwen Li (Author), Liting Huang (Author), Yingyan Kuang (Author), Xiaoxiong Wu (Author), Xiangqiong Ma (Author), Beibei Zhao (Author), Jiao Lan (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The P2X7 receptor (P2X7R), an ATP-gated ion channel, has emerged as a crucial player in neuroinflammation and a promising therapeutic target for neurodegenerative disorders. This review explores the current understanding of P2X7R's structure, activation, and physiological roles, focusing on its...