Novel insights on saccharin- and acesulfame-based carbonic anhydrase inhibitors: design, synthesis, modelling investigations and biological activity evaluation

• Main Authors: Paolo Guglielmi (Author), Giulia Rotondi (Author), Daniela Secci (Author), Andrea Angeli (Author), Paola Chimenti (Author), Alessio Nocentini (Author), Alessandro Bonardi (Author), Paola Gratteri (Author), Simone Carradori (Author), Claudiu T. Supuran (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A large library of saccharin and acesulfame derivatives has been synthesised and evaluated against four isoforms of human carbonic anhydrase, the two off-targets hCA I/II and the tumour related isoforms hCA IX/XII. Different strategies of scaffold modification have been attempted on both saccharin a...