Nicotinic Acetylcholine Receptor α7 Subunit Mediates Migration of Vascular Smooth Muscle Cells Toward Nicotine

• Main Authors: Sheng Li (Author), Tiejun Zhao (Author), Hong Xin (Author), Li-Hong Ye (Author), Xiaodong Zhang (Author), Hideyuki Tanaka (Author), Akio Nakamura (Author), Kazuhiro Kohama (Author)
• Format: Book
• Published: Elsevier, 2004-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

GbaSM-4 cells, vascular smooth muscle cells (VSMCs) derived from brain basilar arteries, were shown to migrate toward d-nicotine by augmenting the actin cytoskeleton in their cell bodies and lamellipodia, and expression of nicotinic acetylcholine receptor (α7-nAChR) was detected in GbaSM-4 cells. Th...