Identification of a small-molecule RPL11 mimetic that inhibits tumor growth by targeting MDM2-p53 pathway

• Main Authors: Bingwu Wang (Author), Jian Gao (Author), Zhongjun Zhao (Author), Xuefei Zhong (Author), Hao Cui (Author), Hui Hou (Author), Yanping Zhang (Author), Junnian Zheng (Author), Jiehui Di (Author), Yong Liu (Author)
• Format: Book
• Published: BMC, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Targeting ribosome biogenesis to activate p53 has recently emerged as a therapeutic strategy in human cancer. Among various ribosomal proteins, RPL11 centralizes the nucleolar stress-sensing pathway by binding MDM2, leading to MDM2 inactivation and p53 activation. Therefore, the...