Mitochondria-Targeted Antioxidants MitoQ and MitoTEMPO Do Not Influence BRAF-Driven Malignant Melanoma and KRAS-Driven Lung Cancer Progression in Mice

• Главные авторы: Kristell Le Gal (Автор), Clotilde Wiel (Автор), Mohamed X. Ibrahim (Автор), Marcus Henricsson (Автор), Volkan I. Sayin (Автор), Martin O. Bergo (Автор)
• Формат: ‌
• Опубликовано: MDPI AG, 2021-01-01T00:00:00Z.
• Предметы: article
• Online-ссылка: Connect to this object online.

Cancer cells produce high levels of mitochondria-associated reactive oxygen species (ROS) that can damage macromolecules, but also promote cell signaling and proliferation. Therefore, mitochondria-targeted antioxidants have been suggested to be useful in anti-cancer therapy, but no studies have conv...