Efficacy of rupatadine in reducing the incidence of dengue haemorrhagic fever in patients with acute dengue: A randomised, double blind, placebo-controlled trial.

• المؤلفون الرئيسيون: Gathsaurie Neelika Malavige (مؤلف), Chandima Jeewandara (مؤلف), Ananda Wijewickrama (مؤلف), Dumni Gunasinghe (مؤلف), Sameera D Mahapatuna (مؤلف), Chathurika Gangani (مؤلف), Vimalahan Vimalachandran (مؤلف), Geethal Jayarathna (مؤلف), Yashoda Perera (مؤلف), Chandanie Wanigatunga (مؤلف), Harsha Dissanayake (مؤلف), Shamini Prathapan (مؤلف), Eranga Narangoda (مؤلف), Damayanthi Idampitiya (مؤلف), Laksiri Gomes (مؤلف), Samurdhi Wickramanayake (مؤلف), Pramodth Sahabandu (مؤلف), Graham S Ogg (مؤلف)
• التنسيق: كتاب
• منشور في: Public Library of Science (PLoS), 2022-06-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

<h4>Background</h4>Rupatadine was previously shown to reduce endothelial dysfunction in vitro, reduced vascular leak in dengue mouse models and to reduce the extent of pleural effusions and thrombocytopenia in patients with acute dengue. Therefore, we sought to determine the efficacy of...