Efficacy of rupatadine in reducing the incidence of dengue haemorrhagic fever in patients with acute dengue: A randomised, double blind, placebo-controlled trial.

• Main Authors: Gathsaurie Neelika Malavige (Author), Chandima Jeewandara (Author), Ananda Wijewickrama (Author), Dumni Gunasinghe (Author), Sameera D Mahapatuna (Author), Chathurika Gangani (Author), Vimalahan Vimalachandran (Author), Geethal Jayarathna (Author), Yashoda Perera (Author), Chandanie Wanigatunga (Author), Harsha Dissanayake (Author), Shamini Prathapan (Author), Eranga Narangoda (Author), Damayanthi Idampitiya (Author), Laksiri Gomes (Author), Samurdhi Wickramanayake (Author), Pramodth Sahabandu (Author), Graham S Ogg (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<h4>Background</h4>Rupatadine was previously shown to reduce endothelial dysfunction in vitro, reduced vascular leak in dengue mouse models and to reduce the extent of pleural effusions and thrombocytopenia in patients with acute dengue. Therefore, we sought to determine the efficacy of...