Triplex-forming oligonucleotides as an anti-gene technique for cancer therapy

• Autores principales: Chun Li (Autor), Zunzhen Zhou (Autor), Chao Ren (Autor), Yi Deng (Autor), Feng Peng (Autor), Qiongfen Wang (Autor), Hong Zhang (Autor), Yuan Jiang (Autor)
• Formato: Libro
• Publicado: Frontiers Media S.A., 2022-12-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Triplex-forming oligonucleotides (TFOs) can bind to the major groove of double-stranded DNA with high specificity and affinity and inhibit gene expression. Triplex-forming oligonucleotides have gained prominence because of their potential applications in antigene therapy. In particular, the target s...