Triplex-forming oligonucleotides as an anti-gene technique for cancer therapy

• Main Authors: Chun Li (Author), Zunzhen Zhou (Author), Chao Ren (Author), Yi Deng (Author), Feng Peng (Author), Qiongfen Wang (Author), Hong Zhang (Author), Yuan Jiang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Triplex-forming oligonucleotides (TFOs) can bind to the major groove of double-stranded DNA with high specificity and affinity and inhibit gene expression. Triplex-forming oligonucleotides have gained prominence because of their potential applications in antigene therapy. In particular, the target s...