Prognostic and predictive biomarkers for hypoxic regions on breast cancer: advances and challenges Biomarcadores preditivos e prognósticos em regiões hipóxicas do câncer de mama: avanços e desafios

• Main Authors: Moacyr Jesus Barreto de Melo Rêgo (Author), Eduardo Isidoro Carneiro Beltrão (Author)
• Format: Book
• Published: Sociedade Brasileira de Patologia Clínica, 2013-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hypoxia has been extensively studied in solid tumors mainly in breast cancers and it is commonly associated with chemotherapy and radiotherapy resistance. Hypoxia inducible factor (HIF)-1α is responsible for hypoxia in the tumor microenvironment and its molecular mechanisms as well as its therapeuti...