miR-23b Negatively Regulates Sepsis-Induced Inflammatory Responses by Targeting ADAM10 in Human THP-1 Monocytes

• Main Authors: Wenying Zhang (Author), Furong Lu (Author), Yuliu Xie (Author), Yao Lin (Author), Tian Zhao (Author), Shoubao Tao (Author), Zhipeng Lai (Author), Ning Wei (Author), Ruoxuan Yang (Author), Yiming Shao (Author), Junbing He (Author)
• Format: Book
• Published: Hindawi Limited, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background. Previous studies have demonstrated pivotal roles of disintegrin and metalloproteinase 10 (ADAM10) in the pathogenesis of sepsis. MicroRNA- (miR-) 23b has emerged as an anti-inflammatory factor that prevents multiple autoimmune diseases. However, the underlying mechanisms of miR-23b in th...