Identification and Characterization of Key Differentially Expressed Genes Associated With Metronomic Dosing of Topotecan in Human Prostate Cancer

• Main Authors: Taraswi Mitra Ghosh (Author), Jason White (Author), Joshua Davis (Author), Suman Mazumder (Author), Teeratas Kansom (Author), Elena Skarupa (Author), Grafton S. Barnett (Author), Gary A. Piazza (Author), R. Curtis Bird (Author), Amit K. Mitra (Author), Clayton Yates (Author), Brian S. Cummings (Author), Robert D. Arnold (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Repetitive, low-dose (metronomic; METRO) drug administration of some anticancer agents can overcome drug resistance and increase drug efficacy in many cancers, but the mechanisms are not understood fully. Previously, we showed that METRO dosing of topotecan (TOPO) is more effective than conventional...