Pdgfrα functions in endothelial-derived cells to regulate neural crest cells and the development of the great arteries

• Main Authors: Haig Aghajanian (Author), Young Kuk Cho (Author), Nicholas W. Rizer (Author), Qiaohong Wang (Author), Li Li (Author), Karl Degenhardt (Author), Rajan Jain (Author)
• Format: Book
• Published: The Company of Biologists, 2017-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Originating as a single vessel emerging from the embryonic heart, the truncus arteriosus must septate and remodel into the aorta and pulmonary artery to support postnatal life. Defective remodeling or septation leads to abnormalities collectively known as conotruncal defects, which are associated wi...