Phosphodiesterase 10A Is a Mediator of Osteogenic Differentiation and Mechanotransduction in Bone Marrow-Derived Mesenchymal Stromal Cells

• 主要な著者: Sigrid Müller-Deubert (著者), Carolin Ege (著者), Melanie Krug (著者), Jutta Meißner-Weigl (著者), Maximilian Rudert (著者), Oliver Bischof (著者), Franz Jakob (著者), Regina Ebert (著者)
• フォーマット: 図書
• 出版事項: Hindawi Limited, 2020-01-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Bone marrow-derived mesenchymal stromal cells (hMSCs) are capable of differentiating into the osteogenic lineage, and for osteogenic differentiation, mechanical loading is a relevant stimulus. Mechanotransduction leads to the formation of second messengers such as cAMP, cGMP, or Ca2+ influx resultin...