Development of PD3 and PD3-B for PDEδ inhibition to modulate KRAS activity

• मुख्य लेखकों: Jungeun Lee (लेखक), Ho Jin Lee (लेखक), Yeongcheol Lee (लेखक), Bumhee Lim (लेखक), Jongsik Gam (लेखक), Dong-Chan Oh (लेखक), Jeeyeon Lee (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Despite extensive efforts over 40 years, few effective KRAS inhibitors have been developed to date, mainly due to the undruggable features of KRAS proteins. In addition to the direct approach to KRAS via covalent inhibition, modulation of the prenyl-binding protein PDEδ that binds with farnesylated...