Development of PD3 and PD3-B for PDEδ inhibition to modulate KRAS activity
Despite extensive efforts over 40 years, few effective KRAS inhibitors have been developed to date, mainly due to the undruggable features of KRAS proteins. In addition to the direct approach to KRAS via covalent inhibition, modulation of the prenyl-binding protein PDEδ that binds with farnesylated...
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Materiálatiipa: | Girji |
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Taylor & Francis Group,
2022-12-01T00:00:00Z.
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