The Role of the FMN-Domain of Human Cytochrome P450 Oxidoreductase in Its Promiscuous Interactions With Structurally Diverse Redox Partners

• Main Authors: Francisco Esteves (Author), Diana Campelo (Author), Bruno Costa Gomes (Author), Philippe Urban (Author), Sophie Bozonnet (Author), Thomas Lautier (Author), José Rueff (Author), Gilles Truan (Author), Michel Kranendonk (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

NADPH cytochrome P450 oxidoreductase (CPR) is the obligatory electron supplier that sustains the activity of microsomal cytochrome P450 (CYP) enzymes. The variant nature of the isoform-specific proximal interface of microsomal CYPs indicates that CPR is capable of multiple degenerated interactions w...