Reduction of biofilm formation of Escherichia coli by targeting quorum sensing and adhesion genes using the CRISPR/Cas9-HDR approach, and its clinical application on urinary catheter

• Main Authors: Maryam Alshammari (Author), Aldossary Ahmad (Author), Manal AlKhulaifi (Author), Dunia Al Farraj (Author), Samar Alsudir (Author), Moahmed Alarawi (Author), Gojobori Takashi (Author), Essam Alyamani (Author)
• Format: Book
• Published: Elsevier, 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Escherichia coli is a common cause of biofilm-associated urinary tract infections (UTIs). Biofilm formation in E. coli is responsible for various indwelling medical device-associated infections, including catheter-associated urinary tract infections (CAUTIs). This study aimed to reduce bi...