Type A1 but Not Type A2 Botulinum Toxin Decreases the Grip Strength of the Contralateral Foreleg Through Axonal Transport From the Toxin-Treated Foreleg of Rats

• Main Authors: Yasushi Torii (Author), Norio Akaike (Author), Tetsuhiro Harakawa (Author), Keiko Kato (Author), Nakaba Sugimoto (Author), Yoshitaka Goto (Author), Shinji Nakahira (Author), Tomoko Kohda (Author), Shunji Kozaki (Author), Ryuji Kaji (Author), Akihiro Ginnaga (Author)
• Format: Book
• Published: Elsevier, 2011-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract.: The adverse effects of botulinum LL toxin and neurotoxin produced by subtype A1 (A1LL and A1NTX) are becoming issues, as the toxins could diffuse from the toxin-treated (ipsilateral) to contralateral muscles. We have attempted to produce neurotoxin from subtype A2 (A2NTX) with an amino ac...