Oral Administration of Curcumin Suppresses Production of Matrix Metalloproteinase (MMP)-1 and MMP-3 to Ameliorate Collagen-Induced Arthritis: Inhibition of the PKCδ/JNK/c-Jun Pathway

• Main Authors: Se Hwan Mun (Author), Hyuk Soon Kim (Author), Jie Wan Kim (Author), Na Young Ko (Author), Do Kyun Kim (Author), Beob Yi Lee (Author), Bokyung Kim (Author), Hyung Sik Won (Author), Hwa-Sup Shin (Author), Jeung-Whan Han (Author), Hoi Young Lee (Author), Young Mi Kim (Author), Wahn Soo Choi (Author)
• Format: Book
• Published: Elsevier, 2009-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We investigated whether oral administration of curcumin suppressed type II collagen-induced arthritis (CIA) in mice and its effect and mechanism on matrix metalloproteinase (MMP)-1 and MMP-3 production in CIA mice, RA fibroblast-like synoviocytes (FLS), and chondrocytes. CIA in mice was suppressed b...