Pharmacokinetic Study of Mucoadhesive Itopride Hydrochloride In Situ Nasal Gel Formulations in a Comparative In Vivo Study and Histopathological Safety Evaluation

• Autori principali: Maha A. Marzouk (Autore), Dina A. Osman (Autore), Amany I. Abd El-Fattah (Autore), Reem A. Aldeeb (Autore)
• Natura: Libro
• Pubblicazione: MDPI AG, 2022-01-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Hepatic first-pass metabolism has been a major cause of reduced bioavailability for many drugs. Using the nasal route as an alternative route to deliver drugs to the systemic circulation provided the solution to this problem. One of the drugs which are highly affected by first-pass metabolism is ito...