A single dose of antibody-drug conjugate cures a stage 1 model of African trypanosomiasis.

• Main Authors: Paula MacGregor (Author), Andrea L Gonzalez-Munoz (Author), Fatoumatta Jobe (Author), Martin C Taylor (Author), Steven Rust (Author), Alan M Sandercock (Author), Olivia J S Macleod (Author), Katrien Van Bocxlaer (Author), Amanda F Francisco (Author), Francois D'Hooge (Author), Arnaud Tiberghien (Author), Conor S Barry (Author), Philip Howard (Author), Matthew K Higgins (Author), Tristan J Vaughan (Author), Ralph Minter (Author), Mark Carrington (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2019-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Infections of humans and livestock with African trypanosomes are treated with drugs introduced decades ago that are not always fully effective and often have severe side effects. Here, the trypanosome haptoglobin-haemoglobin receptor (HpHbR) has been exploited as a route of uptake for an antibody-dr...