A single dose of antibody-drug conjugate cures a stage 1 model of African trypanosomiasis.

• Главные авторы: Paula MacGregor (Автор), Andrea L Gonzalez-Munoz (Автор), Fatoumatta Jobe (Автор), Martin C Taylor (Автор), Steven Rust (Автор), Alan M Sandercock (Автор), Olivia J S Macleod (Автор), Katrien Van Bocxlaer (Автор), Amanda F Francisco (Автор), Francois D'Hooge (Автор), Arnaud Tiberghien (Автор), Conor S Barry (Автор), Philip Howard (Автор), Matthew K Higgins (Автор), Tristan J Vaughan (Автор), Ralph Minter (Автор), Mark Carrington (Автор)
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• Опубликовано: Public Library of Science (PLoS), 2019-05-01T00:00:00Z.
• Предметы: article
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Infections of humans and livestock with African trypanosomes are treated with drugs introduced decades ago that are not always fully effective and often have severe side effects. Here, the trypanosome haptoglobin-haemoglobin receptor (HpHbR) has been exploited as a route of uptake for an antibody-dr...