Icariin Ameliorates Palmitate-Induced Insulin Resistance Through Reducing Thioredoxin-Interacting Protein (TXNIP) and Suppressing ER Stress in C2C12 Myotubes

• Главные авторы: Mingxin Li (Автор), Yemin Zhang (Автор), Yingkang Cao (Автор), Deling Zhang (Автор), Le Liu (Автор), Yanghongyun Guo (Автор), Changhua Wang (Автор)
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• Опубликовано: Frontiers Media S.A., 2018-10-01T00:00:00Z.
• Предметы: article
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Both thioredoxin-interacting protein (TXNIP) and endoplasmic reticulum (ER) stress are implicated in skeletal muscle insulin resistance. Icariin has been found to mimic insulin action in normal skeletal muscle C2C12 cells and display anti-diabetic properties in diet-induced obese mice. However, the...