Trametinib Sensitivity is Defined by a Myeloid Differentiation Profile in Acute Myeloid Leukemia

• Main Authors: Mathieu Quesnel-Vallières (Author), David C. Schultz (Author), Alena Orlenko (Author), Yancy Lo (Author), Jason Moore (Author), Marylyn Ritchie (Author), David Roth (Author), Martin Carroll (Author), Yoseph Barash (Author), Kristen W. Lynch (Author), Sara Cherry (Author)
• Format: Book
• Published: Adis, Springer Healthcare, 2024-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background and Objective Acute myelogenous leukemia (AML) is a common blood cancer marked by heterogeneity in disease and diverse genetic abnormalities. Additional therapies are needed as the 5-year survival remains below 30%. Trametinib is a mitogen-activated extracellular signal-regulated...