Enrichment analysis of phenotypic data for drug repurposing in rare diseases

• Main Authors: Alberto Ambesi-Impiombato (Author), Kimberly Cox (Author), Sylvie Ramboz (Author), Daniela Brunner (Author), Mukesh Bansal (Author), Emer Leahy (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Drug-induced Behavioral Signature Analysis (DBSA), is a machine learning (ML) method for in silico screening of compounds, inspired by analytical methods quantifying gene enrichment in genomic analyses. When applied to behavioral data it can identify drugs that can potentially reverse in vivo behavi...