Combined melatonin and poricoic acid A inhibits renal fibrosis through modulating the interaction of Smad3 and β-catenin pathway in AKI-to-CKD continuum

• Autori principali: Dan-Qian Chen (Autore), Gang Cao (Autore), Hui Zhao (Autore), Lin Chen (Autore), Tian Yang (Autore), Ming Wang (Autore), Nosratola D. Vaziri (Autore), Yan Guo (Autore), Ying-Yong Zhao (Autore)
• Natura: Libro
• Pubblicazione: SAGE Publishing, 2019-08-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Background: Acute kidney injury (AKI) is one of the major risk factors for progression to chronic kidney disease (CKD) and renal fibrosis. However, effective therapies remain poorly understood. Here, we examined the renoprotective effects of melatonin and poricoic acid A (PAA) isolated from the surf...