The L1 cell adhesion molecule constrains dendritic spine density in pyramidal neurons of the mouse cerebral cortex

• Main Authors: Kelsey E. Murphy (Author), Sarah D. Wade (Author), Justin E. Sperringer (Author), Vishwa Mohan (Author), Bryce W. Duncan (Author), Erin Y. Zhang (Author), Yubin Pak (Author), David Lutz (Author), Melitta Schachner (Author), Patricia F. Maness (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A novel function for the L1 cell adhesion molecule, which binds the actin adaptor protein Ankyrin was identified in constraining dendritic spine density on pyramidal neurons in the mouse neocortex. In an L1-null mouse mutant increased spine density was observed on apical but not basal dendrites of p...