Pharmacokinetics and Pharmacodynamics of Nemonoxacin in a Neutropenic Murine Lung Infection Model Against Streptococcus Pneumoniae

• Main Authors: Xin Li (Author), Yuancheng Chen (Author), Xiaoyong Xu (Author), Yi Li (Author), Yaxin Fan (Author), Xiaofen Liu (Author), Xingchen Bian (Author), Hailan Wu (Author), Xu Zhao (Author), Meiqing Feng (Author), Beining Guo (Author), Jing Zhang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Nemonoxacin, a novel nonfluorinated quinolone for the treatment of community-acquired pneumonia. We reported the pharmacokinetic/pharmacodynamic (PK/PD) targets and PK/PD breakpoints of nemonoxacin against Streptococcus pneumoniae using a neutropenic murine lung infection model. Single-dose PK analy...