Novel small molecule retrograde transport blocker confers post-exposure protection against ricin intoxication

• Main Authors: Xu Zhao (Author), Haixia Li (Author), Jia Li (Author), Kunlu Liu (Author), Bo Wang (Author), Yuxia Wang (Author), Xingzhou Li (Author), Wu Zhong (Author)
• Format: Book
• Published: Elsevier, 2020-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Ricin is a highly toxic type 2 ribosome-inactivating protein (RIP) which is extracted from the seeds of castor beans. Ricin is considered a potential bioterror agent and no effective antidote for ricin exists so far. In this study, by structural modification of a retrograde transport blocker Retro-2...