Directed evolution of adeno-associated virus 5 capsid enables specific liver tropism

• Main Authors: Yuqiu Wang (Author), Chen Yang (Author), Hanyang Hu (Author), Chen Chen (Author), Mengdi Yan (Author), Feixiang Ling (Author), Kathy Cheng Wang (Author), Xintao Wang (Author), Zhe Deng (Author), Xinyue Zhou (Author), Feixu Zhang (Author), Sen Lin (Author), Zengmin Du (Author), Kai Zhao (Author), Xiao Xiao (Author)
• Format: Book
• Published: Elsevier, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Impressive achievements in clinical trials to treat hemophilia establish a milestone in the development of gene therapy. It highlights the significance of AAV-mediated gene delivery to liver. AAV5 is a unique serotype featured by low neutralizing antibody prevalence. Nevertheless, its liver infectiv...