A bootstrapping method to optimize go/no‐go decisions from single‐arm, signal‐finding studies in oncology

• Asıl Yazarlar: Raunak Dutta (Yazar), Aparna Mohan (Yazar), Jacqueline Buros‐Novik (Yazar), Gregory Goldmacher (Yazar), Omobolaji O. Akala (Yazar), Brian Topp (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Wiley, 2024-08-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Abstract Phase Ib trials are common in oncology development but often are not powered for statistical significance. Go/no‐go decisions are largely driven by observed trends in response data. We applied a bootstrapping method to systematically compare tumor dynamic end points to historical control da...