Rodent models in Down syndrome research: impact and future opportunities

• Autori principali: Yann Herault (Autore), Jean M. Delabar (Autore), Elizabeth M. C. Fisher (Autore), Victor L. J. Tybulewicz (Autore), Eugene Yu (Autore), Veronique Brault (Autore)
• Natura: Libro
• Pubblicazione: The Company of Biologists, 2017-10-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Down syndrome is caused by trisomy of chromosome 21. To date, a multiplicity of mouse models with Down-syndrome-related features has been developed to understand this complex human chromosomal disorder. These mouse models have been important for determining genotype-phenotype relationships and ident...