The N-Methyl-D-Aspartate Receptor Blocker REL-1017 (Esmethadone) Reduces Calcium Influx Induced by Glutamate, Quinolinic Acid, and Gentamicin

• Main Authors: Ezio Bettini (Author), Sara De Martin (Author), Andrea Mattarei (Author), Marco Pappagallo (Author), Stephen M. Stahl (Author), Francesco Bifari (Author), Charles E. Inturrisi (Author), Franco Folli (Author), Sergio Traversa (Author), Paolo L. Manfredi (Author)
• Format: Book
• Published: MDPI AG, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

REL-1017 (esmethadone) is a novel N-methyl-D-aspartate receptor (NMDAR) antagonist and promising rapid antidepressant candidate. Using fluorometric imaging plate reader (FLIPR) assays, we studied the effects of quinolinic acid (QA) and gentamicin, with or without L-glutamate and REL-1017, on intrace...