CCND1 copy number increase and cyclin D1 expression in acral melanoma: a comparative study of fluorescence in situ hybridization and immunohistochemistry in a Chinese cohort

• Main Authors: Jianying Liu (Author), Wenjuan Yu (Author), Fei Gao (Author), Shuangshuang Qi (Author), Juan Du (Author), Xiaolong Ma (Author), Yan Zhang (Author), Jie Zheng (Author), Jing Su (Author)
• Format: Book
• Published: BMC, 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background CCND1 copy number increase is characteristic of acral melanoma and is useful in distinguishing benign and malignant acral melanocytic lesions. Increase of the gene copy number may result in protein overexpression. This raises the possibility that detection of high expression of c...