Synthesis, pharmacology and molecular docking on multifunctional tacrine-ferulic acid hybrids as cholinesterase inhibitors against Alzheimer's disease

• Main Authors: Jie Zhu (Author), Hongyu Yang (Author), Yao Chen (Author), Hongzhi Lin (Author), Qi Li (Author), Jun Mo (Author), Yaoyao Bian (Author), Yuqiong Pei (Author), Haopeng Sun (Author)
• Format: Book
• Published: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The cholinergic hypothesis has long been a "polar star" in drug discovery for Alzheimer's disease (AD), resulting in many small molecules and biological drug candidates. Most of the drugs marketed for AD are cholinergic. Herein, we report our efforts in the discovery of cholinesterase...