Synthesis of Novel Artemisinin, Ciprofloxacin, and Norfloxacin Hybrids with Potent Antiplasmodial Activity

• Main Authors: Georgia Vamvoukaki (Author), Antonia I. Antoniou (Author), Michel Baltas (Author), Elisabeth Mouray (Author), Sebastien Charneau (Author), Philippe Grellier (Author), Constantinos M. Athanassopoulos (Author)
• Format: Book
• Published: MDPI AG, 2024-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The synthesis and antiplasmodial evaluation of new hybrids combining the pharmacophore structures of artemisinin, ciprofloxacin or norfloxacin, and 7-chloroquinoline are reported in this study. The first step for all of the syntheses is the obtainment of key piperazine esters intermediates bearing t...