FGF21 alleviates endothelial mitochondrial damage and prevents BBB from disruption after intracranial hemorrhage through a mechanism involving SIRT6

• Autores principales: Runfeng Wang (Autor), Jin Wang (Autor), Zhiguo Zhang (Autor), Bo Ma (Autor), Shukai Sun (Autor), Li Gao (Autor), Guodong Gao (Autor)
• Formato: Libro
• Publicado: BMC, 2023-12-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Abstract Background Disruption of the BBB is a harmful event after intracranial hemorrhage (ICH), and this disruption contributes to a series of secondary injuries. We hypothesized that FGF21 may have protective effects after intracranial hemorrhage (ICH) and investigated possible underlying molecul...