Evaluation of the Binding Characteristics of [5-11C-methoxy]Donepezil in the Rat Brain for In Vivo Visualization of Acetylcholinesterase

• Main Authors: Yoshihito Funaki (Author), Motohisa Kato (Author), Ren Iwata (Author), Eiko Sakurai (Author), Eiichi Sakurai (Author), Manabu Tashiro (Author), Tatsuo Ido (Author), Kazuhiko Yanai (Author)
• Format: Book
• Published: Elsevier, 2003-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Donepezil, an acetylcholinesterase (AChE) inhibitor, has not been evaluated for its binding characteristics using a radioactive tracer, although its inhibitory action on AChE has been studied. The aim of this research is to examine whether AChE can be visualized in vivo and in vitro with [11C]donepe...