Evaluation of the Binding Characteristics of [5-11C-methoxy]Donepezil in the Rat Brain for In Vivo Visualization of Acetylcholinesterase

• Glavni autori: Yoshihito Funaki (Autor), Motohisa Kato (Autor), Ren Iwata (Autor), Eiko Sakurai (Autor), Eiichi Sakurai (Autor), Manabu Tashiro (Autor), Tatsuo Ido (Autor), Kazuhiko Yanai (Autor)
• Format: Knjiga
• Izdano: Elsevier, 2003-01-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Donepezil, an acetylcholinesterase (AChE) inhibitor, has not been evaluated for its binding characteristics using a radioactive tracer, although its inhibitory action on AChE has been studied. The aim of this research is to examine whether AChE can be visualized in vivo and in vitro with [11C]donepe...