Dose-dependent reduction of lymphocyte count and heart rate after multiple administration of LC51-0255, a novel sphingosine-1-phosphate receptor 1 modulator, in healthy subjects

Aim: Sphingosine-1-phosphate receptor mediates the egress of lymphocytes from lymphoid organs, and its inhibition results in a decreased number of circulating lymphocytes. The aim of the current study was to investigate the safety and pharmacodynamic and pharmacokinetic characteristics of a novel sp...

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Main Authors: Inyoung Hwang (Author), Sang Won Lee (Author), Jaeseong Oh (Author), SeungHwan Lee (Author), In-Jin Jang (Author), Kyung-Sang Yu (Author)
Format: Book
Published: Frontiers Media S.A., 2022-08-01T00:00:00Z.
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3rd Floor Main Library

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