Neurons undergo pathogenic metabolic reprogramming in models of familial ALS

• Main Authors: Sean-Patrick Riechers (Author), Jelena Mojsilovic-Petrovic (Author), Tayler B. Belton (Author), Ram P. Chakrabarty (Author), Mehraveh Garjani (Author), Valentina Medvedeva (Author), Casey Dalton (Author), Yvette C. Wong (Author), Navdeep S. Chandel (Author), Gerald Dienel (Author), Robert G. Kalb (Author)
• Format: Book
• Published: Elsevier, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Objectives: Normal cellular function requires a rate of ATP production sufficient to meet demand. In most neurodegenerative diseases (including Amyotrophic Lateral Sclerosis [ALS]), mitochondrial dysfunction is postulated raising the possibility of impaired ATP production and a need for com...