Targeting hexokinase 2 for oral cancer therapy: structure-based design and validation of lead compounds

• Main Authors: Purbali Chakraborty (Author), Syeda Lubna (Author), Shouvik Bhuin (Author), Deepika K. (Author), Manab Chakravarty (Author), Trinath Jamma (Author), Perumal Yogeeswari (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The pursuit of small molecule inhibitors targeting hexokinase 2 (HK2) has significantly captivated the field of cancer drug discovery. Nevertheless, the creation of selective inhibitors aimed at specific isoforms of hexokinase (HK) remains a formidable challenge. Here, we present a multiple-pharmaco...