SORLA mediates endocytic uptake of proIAPP and protects against islet amyloid deposition

• Main Authors: Alexis Z.L. Shih (Author), Yi-Chun Chen (Author), Thilo Speckmann (Author), Esben Søndergaard (Author), Annette Schürmann (Author), C. Bruce Verchere (Author), Thomas E. Willnow (Author)
• Format: Book
• Published: Elsevier, 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Sorting-related receptor with type A repeats (SORLA) is a neuronal sorting receptor that prevents accumulation of amyloid-beta peptides, the main constituent of senile plaques in Alzheimer disease. Recent transcriptomic studies show that SORLA transcripts are also found in beta cells of p...