Taxifolin Prevents Cisplatin Nephrotoxicity by Modulating Nrf2/HO-1 Pathway and Mitigating Oxidative Stress and Inflammation in Mice

• Main Authors: Abdulkareem A. Alanezi (Author), Afaf F. Almuqati (Author), Manal A. Alfwuaires (Author), Fawaz Alasmari (Author), Nader I. Namazi (Author), Osama Y. Althunibat (Author), Ayman M. Mahmoud (Author)
• Format: Book
• Published: MDPI AG, 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cisplatin (CIS) is an effective chemotherapeutic agent used in the treatment of several malignancies. The clinical use of CIS is associated with adverse effects, including acute kidney injury (AKI). Oxidative stress and inflammation are key events in the development of CIS-induced AKI. This study in...