Correlation of thiopurine methyltransferase and inosine triphosphate pyrophosphatase polymorphisms and adverse effects induced by azathioprine treatment in Taiwanese dermatology patients

• Main Authors: Ting-Shun Wang (Author), Hsien-Yi Chiu (Author), Lawrence Shih-Hsin Wu (Author), Chia-Yu Chu (Author), Tsen-Fang Tsai (Author)
• Format: Book
• Published: Wolters Kluwer Medknow Publications, 2014-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Azathioprine is used as an immunosuppressant and corticosteroid-sparing agent for the treatment of several cutaneous diseases. The mutation of thiopurine methyltransferase (TPMT) and inosine triphosphate pyrophosphatase (ITPA) has been reported to result in the accumulation of toxic thio...