Transcriptomic analysis reveals the regulatory mechanism underlying the indirubin-mediated amelioration of dextran sulfate sodium-induced colitis in mice

• Main Authors: Zhe Liu (Author), Jin-ru Zhang (Author), Yong-xiang Huang (Author), Xue-ying Li (Author), Hai-peng Zhu (Author), Rui-yi Yang (Author), Song Chen (Author)
• Formato: Livro
• Publicado em: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

AbstractContext Aryl hydrocarbon receptor (AhR) agonists are potential therapeutic agents for ulcerative colitis (UC). Indirubin (IDR), which is a natural AhR ligand approved for leukemia treatment, ameliorates dextran sulfate sodium (DSS)-induced colitis in mice. However, the therapeutic mechanisms...