Optimizing the design of a pharmacokinetic trial to evaluate the dosing scheme of a novel tuberculosis drug in children living with or without HIV

• Main Authors: Grace Montepiedra (Author), Elin M. Svensson (Author), Weng Kee Wong (Author), Andrew C. Hooker (Author)
• 格式: 圖書
• 出版: Wiley, 2024-02-01T00:00:00Z.
• 主題: article
• 在線閱讀: Connect to this object online.

Abstract Pharmacokinetic (PK) studies in children are usually small and have ethical constraints due to the medical complexities of drawing blood in this special population. Often, population PK models for the drug(s) of interest are available in adults, and these models can be extended to incorpora...