Engineering of a Long-Acting Bone Morphogenetic Protein-7 by Fusion with Albumin for the Treatment of Renal Injury

• Main Authors: Mei Takano (Author), Shota Toda (Author), Hiroshi Watanabe (Author), Rui Fujimura (Author), Kento Nishida (Author), Jing Bi (Author), Yuki Minayoshi (Author), Masako Miyahisa (Author), Hitoshi Maeda (Author), Toru Maruyama (Author)
• Format: Book
• Published: MDPI AG, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The bone morphogenetic protein-7 (BMP7) is capable of inhibiting TGF-β/Smad3 signaling, which subsequently results in protecting the kidney from renal fibrosis, but its lower blood retention and osteogenic activity are bottlenecks for its clinical application. We report herein on the fusion of carbo...